Can you take amoxicillin while pregnant

Although most antibiotics are not recommended for use during pregnancy, some penicillin medications, including amoxicillin, are considered safe to take [1]. They are usually prescribed for treating bacterial conditions such as UTIs [2], pneumonia [3], sinus infections [4], acute bronchitis, as well as some lung and middle ear infections [5].The possible risks may depend on the dosage of the medication and the condition it is being used for. So, it is essential that you consult with your doctor to avoid any risks of complication or contraindication [6].

Women allergic to penicillins should avoid its use [7].

Amoxicillin FDA Pregnancy Category

It is listed in the FDA Category B [8] as no harmful effects have been recorded in animal pregnancy. However, there is limited data available about its effects on a human fetus.

Is amoxicillin safe during the first trimester

Studies have shown no increased risk of fetal damage due to the use of amoxicillin in early pregnancy [9]. However, more research is required.

How much amoxicillin is safe during pregnancy

It is a prescription drug [10], so consult your doctor regarding the safe dosage specific to your pregnancy and requirement. Antibiotics are prescribed to pregnant women only when the potential benefits outweigh the possible risks [11]. Make sure to stick to the dosage recommended by your physician as wrong dosage or overdose might lead to serious complications.

Risks of taking amoxicillin in pregnancy

One study, performed with 106 pregnant women who were prescribed amoxicillin in the second or third trimesters for premature rupture of membranes, found no evidence of any harmful effects on the fetus.

A case-control study, that included 6,935 women with babies having congenital defects and 10,238 women with healthy babies, showed no association of a higher use of Augmentin (amoxicillin-clavulanate combination) with the birth defect group.

The Michigan Medicaid Birth Defects Study [12], carried out between 1985 and 1992, observed 229,101 pregnant women, among whom 8,538 took amoxicillin in the first trimester. No associations were found between first-trimester exposure to the drug and any major fetal malformations.

No increased risk of fetal abnormalities were found in a study performed by The Collaborative Perinatal Project, where 3546 pregnant women, who took the drug in the first trimester, and 7171 women, who took the drug any time in their pregnancy were observed.

Amoxicillin and breastfeeding

It is usually considered safe for use in breastfeeding mothers and is even sometimes prescribed to nursing infants to treat infections [10]. However, it is necessary to consult your doctor before use as the drug may excrete in the breast milk in small amounts, posing a risk of diarrhea and other allergic reactions in the baby [13].

[ref]

  1. http://www.babycenter.com/404_is-it-safe-to-take-antibiotics-during-pregnancy_1362964.bc
  2. http://www.cfp.ca/content/54/6/853.full
  3. http://www.medscape.com/viewarticle/717402_7
  4. http://americanpregnancy.org/pregnancy-complications/sinus-infection-while-pregnant/
  5. http://www.medicinesinpregnancy.org/Medicine–pregnancy/Amoxicillin/
  6. http://www.aafp.org/afp/2006/0915/p1035.html
  7. http://www.nhs.uk/medicine-guides/pages/MedicineOverview.aspx?condition=Bacterial%20infections&medicine=Amoxicillin%20trihydrate&preparationAmoxicillin%20250mg%20capsules
  8. http://reference.medscape.com/drug/amoxil-moxatag-amoxicillin-342473#6
  9. http://www.fda.gov/Drugs/EmergencyPreparedness/BioterrorismandDrugPreparedness/ucm072124.htm
  10. http://www.medicinenet.com/amoxicillin/article.htm
  11. http://www.webmd.com/drugs/2/drug-1531-295/amoxicillin-oral/amoxicillinsuspension-oral/details#precautions
  12. http://www.drugs.com/pregnancy/amoxicillin.html
  13. http://www.everydayhealth.com/drugs/amoxicillin [/ref]